Tumour heterogeneity and the evolutionary trade-offs of cancer
Abstract
Tumours vary in gene expression programmes and genetic alterations. Understanding this diversity and its biological meaning requires a theoretical framework, which could in turn guide the development of more accurate prognosis and therapy. Here, we review the theory of multi-task evolution of cancer, which is based upon the premise that tumours evolve in the host and face selection trade-offs between multiple biological functions. This theory...
Paper Details
Title
Tumour heterogeneity and the evolutionary trade-offs of cancer
Published Date
Feb 24, 2020
Journal
Volume
20
Issue
4
Pages
247 - 257
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