Positive feedback loop regulates PGE2 production in nasal fibroblasts
Volume: 145, Issue: 2, Pages: AB148 - AB148
Published: Feb 1, 2020
Abstract
Nasal fibroblasts from subjects with nasal polyps display impaired production of prostaglandin (PG) E2 compared with controls for incompletely understood reasons. PGE2 produced by human amnion fibroblasts can amplify cyclooxygenase (COX)2 expression and PGE2 synthesis via EP2/EP4 with the cyclic adenosine 3’, 5’-monophosphate (cAMP) and Protein kinase A (PKA) pathway. Whether a PGE2-dependent feed-forward loop regulates COX-2 in nasal...
Paper Details
Title
Positive feedback loop regulates PGE2 production in nasal fibroblasts
Published Date
Feb 1, 2020
Volume
145
Issue
2
Pages
AB148 - AB148
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