Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress

Volume: 30, Issue: 7, Pages: 2430 - 2443.e4
Published: Feb 1, 2020
Abstract
•Misfolded proteins collapse into protein aggregate centers (PACs) upon heat shock•PAC formation requires the Hsp40 chaperone Mas5•PACs serve as seed for the nucleation of stress granules at severe temperatures•The fate of PACs is refolding, as they protect misfolded proteins from degradation Cells have developed protein quality-control strategies to manage the accumulation of misfolded substrates during heat stress. Using a soluble reporter of...
Paper Details
Title
Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress
Published Date
Feb 1, 2020
Volume
30
Issue
7
Pages
2430 - 2443.e4
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