Obtaining transition rates from single-channel data without initial parameter seeding
Abstract
Background and Purpose: Ion-channels are membrane proteins that can adopt several distinct structural conformations. Some of the conformations are open and allow the passage of ions through the membrane; others are closed and hinder ion flow. Patch-clamp recordings of single ion-channels show if a channel is open or closed, but does not immediately reveal the underlying mechanism, which typically includes several open and closed...
Paper Details
Title
Obtaining transition rates from single-channel data without initial parameter seeding
Published Date
Jan 1, 2020
Journal
Volume
14
Issue
1
Pages
87 - 97
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Notes
History