Coexistence of D3R typical and atypical signaling in striatonigral neurons during dopaminergic denervation. Correlation with D3nf expression changes
Abstract
Dopamine D 3 R are widely expressed in basal ganglia where interact with D 1 R. D 3 R potentiate cAMP accumulation and GABA release stimulated by D 1 R in striatonigral neurons through “atypical” signaling. During dopaminergic denervation, D 3 R signaling changes to a “typical” in which antagonizes the effects of D 1 R, the mechanisms of this switching are unknown. D 3 nf splice variant regulates membrane anchorage and function of D 3 R and...
Paper Details
Title
Coexistence of D3R typical and atypical signaling in striatonigral neurons during dopaminergic denervation. Correlation with D3nf expression changes
Published Date
Mar 6, 2020
Journal
Volume
74
Issue
8
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