Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway

Volume: 14
Published: Feb 28, 2020
Abstract
Fragile X mental retardation protein (FMRP) is an RNA binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance. We previously demonstrated that FMRP is involved in growth cone collapse translation-dependently in response to Semaphorin-3A (Sema3A), a repulsive axon guidance factor. In the case of attractive axon guidance factors, RNA...
Paper Details
Title
Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway
Published Date
Feb 28, 2020
Volume
14
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