Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice
Abstract
Pulmonary fibrosis is a progressive chronic inflammatory lung disease whose pathogenesis is complicated. Platelets and neutrophils play important roles in the progression of pulmonary inflammation. We have reported that cangrelor, a non-sepesific GPR17 antagonist, alleviates pulmonary fibrosis partly by inhibiting macrophage inflammation in mice. Cangrelor is also a well-known anti-platelet agent. To test whether cangrelor mitigated pulmonary...
Paper Details
Title
Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice
Published Date
Apr 1, 2020
Journal
Volume
120
Pages
83 - 92
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