Nanotherapeutics in glioma management: Advances and future perspectives

Published on Jun 1, 2020in Journal of Drug Delivery Science and Technology2.606
· DOI :10.1016/J.JDDST.2020.101626
Abstract Glioblastoma Multiforme management is one the most challenging task in clinical oncology. The blood brain barrier (BBB) possesses a huge hurdle for the brain in terms of drug delivery. In a healthy brain, it performs important functions such as protecting the brain from harmful toxins by not allowing them to cross the BBB. However, in glioma, the normal composition of the BBB is disrupted which makes it difficult for the entry of drugs to the targeted site. This review provides a brief overview on the various strategies employed to treat glioma. The various strategies employed to treat glioma includes surgery, chemotherapy, radiotherapy, angiogenesis inhibitors, alternating electric field therapy and gamma knife surgery. All the current strategies employed in treating glioma possess its own pros and cons. Though surgery is widely followed, removal of the entire tumor is difficult due to the invasive nature of the cancer cells and there is a high chance of relapse. Chemotherapy also fails since many of the drugs cannot cross the blood brain barrier. Gamma knife surgery is effective since high dose of radiations are used but the treatment is very expensive and is not affordable by all the patients. Hence there is a need to find an alternative strategy to treat glioma which is effective and affordable. Currently the most advanced technology in treating glioma is by introducing nanotherapeutics, which ensures the targeted delivery.
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