PAC proton-activated chloride channel contributes to acid-induced cell death in primary rat cortical neurons
Abstract
Severe local acidosis causes tissue damage and pain, and is associated with many diseases, including cerebral and cardiac ischemia, cancer, infection, and inflammation. However, the molecular mechanisms of the cellular response to extracellular acidic environment are not fully understood. We recently identified a novel and evolutionarily conserved membrane protein, PAC (also known as PACC1 or TMEM206), encoding the proton-activated chloride...
Paper Details
Title
PAC proton-activated chloride channel contributes to acid-induced cell death in primary rat cortical neurons
Published Date
Jan 1, 2020
Journal
Volume
14
Issue
1
Pages
53 - 58
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