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Advances in physiological functions and mechanisms of (-)-epicatechin.

Published on Feb 23, 2020in Critical Reviews in Food Science and Nutrition6.704
· DOI :10.1080/10408398.2020.1723057
Zhihao Qu (HAU: Hunan Agricultural University), Ailing Liu1
Estimated H-index: 1
(HAU: Hunan Agricultural University)
+ 5 AuthorsSheng Zhang1
Estimated H-index: 1
(HAU: Hunan Agricultural University)
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Abstract
Abstract(−)-Epicatechin (EC) is a flavanol easily obtained through the diet and is present in tea, cocoa, vegetables, fruits, and cereals. Recent studies have shown that EC protects human health an...
  • References (215)
  • Citations (0)
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References215
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#1Dragan Milenkovic (UC Davis: University of California, Davis)H-Index: 21
#2Ken Declerck (University of Antwerp)H-Index: 9
Last. Wim Vanden Berghe (University of Antwerp)H-Index: 45
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Abstract Ingestion of (−)-epicatechin flavanols reverses endothelial dysfunction by increasing flow mediated dilation and by reducing vascular inflammation and oxidative stress, monocyte-endothelial cell adhesion and transendothelial monocyte migration in vitro and in vivo. This involves multiple changes in gene expression and epigenetic DNA methylation by poorly understood mechanisms. By in silico docking and molecular modeling we demonstrate favorable binding of different glucuronidated, sulfa...
5 CitationsSource
#1M.E. Alañón (University of Reading)H-Index: 1
#2S.M. Castle (University of Reading)H-Index: 1
Last. Jeremy P. E. Spencer (University of Reading)H-Index: 69
view all 7 authors...
Summary Background & aims There is convincing clinical evidence to suggest that flavanol-containing foods/beverages are capable of inducing improvements in human vascular function. However, whilst (-)-epicatechin has been tested for efficacy, a full dose-dependency has yet to be established, particularly at doses below 1 mg/kg BW. The current study examined the dose-dependent effects of (-)-epicatechin on human vascular function with concurrent measurement of plasma (-)-epicatechin metabolites a...
2 CitationsSource
#1Penghui Li (HAU: Hunan Agricultural University)H-Index: 1
#2Ailing Liu (HAU: Hunan Agricultural University)H-Index: 1
Last. Zhonghua Liu (HAU: Hunan Agricultural University)H-Index: 5
view all 8 authors...
AbstractMuscle-related disorders, such as sarcopenia and cachexia, caused by aging and chronic diseases can lead to the loss of muscle mass and strength to different degrees, severely affecting hum...
3 CitationsSource
#1Paula D. Prince (UBA: University of Buenos Aires)H-Index: 4
#2Cesar G. Fraga (UBA: University of Buenos Aires)H-Index: 53
Last. Monica Galleano (UBA: University of Buenos Aires)H-Index: 22
view all 3 authors...
(–)-Epicatechin, a flavonoid omnipresent in plants being part of the human diet, has been associated to beneficial effects on cardiovascular health. The aim of this work was to evaluate the protective effect of (–)-epicatechin of NO deprivated animals on kidney, and the possible mechanism of action. To address the effects of the inhibition of NO synthases (NOSs) by their inhibitor N(ω)-nitro-L-arginine methyl ester (L-NAME) administration in the absence of the long-term effects of NO deprivation...
1 CitationsSource
#1Ziwei Wang (UC Davis: University of California, Davis)H-Index: 1
#2M. Corina Litterio (UBA: University of Buenos Aires)H-Index: 1
Last. Patricia I. Oteiza (UC Davis: University of California, Davis)H-Index: 47
view all 5 authors...
Abstract Secondary bile acids promote gastrointestinal (GI) tract permeabilization both in vivo and in vitro. Consumption of high fat diet s increases bile acid levels in the GI tract which can contribute to intestinal permeabilization and consequent local and systemic inflammation. This work investigated the mechanisms involved in bile acid (deoxycholic acid (DCA))-induced intestinal epithelial cell monolayer permeabilization and the preventive capacity of (-)-epicatechin (EC). While EC prevent...
2 CitationsSource
#1Sundeep DugarH-Index: 21
#2Francisco Villarreal (UCSD: University of California, San Diego)H-Index: 40
Last. George F. SchreinerH-Index: 32
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Abstract Currently, there is great interest in identifying endogenous (i.e. physiological) stimulators of mitochondrial biogenesis (MB), in particular, those that may mediate the effects of exercise. The molecular structure of the cacao flavanols (epicatechin and catechin) highly resembles that of sterols and epicatechin, has been reported to activate cells surface receptors leading to the stimulation of MB in endothelial and skeletal muscle cells translating into enhanced exercise capacity. We ...
1 CitationsSource
#1Thomas Sinegre (INRA: Institut national de la recherche agronomique)H-Index: 4
#2Dorian Teissandier (INRA: Institut national de la recherche agronomique)H-Index: 1
Last. Aurélien Lebreton (INRA: Institut national de la recherche agronomique)H-Index: 2
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The different stages of hemostasis (i.e., primary hemostasis, coagulation and fibrinolysis) are involved in the early atherothrombosis steps. The aim of this study was to investigate the effect of epicatechin, a major flavonoid compound, on the hemostasis phenotype using clinically relevant in vitro global assays that mimic the complexity of the in vivo hemostasis systems. Plasma samples from 10 healthy volunteers were spiked with increasing concentrations of epicatechin (1 to 100 μM). Epicatech...
1 CitationsSource
#1Penghui Li (HAU: Hunan Agricultural University)H-Index: 1
#2Ailing Liu (HAU: Hunan Agricultural University)H-Index: 1
Last. Sheng Zhang (HAU: Hunan Agricultural University)H-Index: 1
view all 8 authors...
Abstract Muscle degeneration and cachexia caused by aging and chronic diseases seriously reduce the quality of life of patients. Catechins in tea enhance skeletal muscle performance, but the specific function and mechanism require further exploration. Myogenic differentiation is accompanied by extensive changes in cell morphology and gene expression patterns. In this study, we measured the number, length, diameter, and transcriptional levels of MyoD, MyoG, and MyHC of myotubes after C2C12 cell d...
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#1Hongwei Si (Tennessee State University)H-Index: 16
#2Xiaoyong Wang (Tennessee State University)H-Index: 2
Last. Chao-Qiang Lai (USDA: United States Department of Agriculture)H-Index: 39
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We recently reported that epicatechin, a bioactive compound that occurs naturally in various common foods, promoted general health and survival of obese diabetic mice. It remains to be determined whether epicatechin extends health span and delays the process of aging. In the present study, epicatechin or its analogue epigallocatechin gallate (EGCG) (0.25% w/v in drinking water) was administered to 20-mo-old male C57BL mice fed a standard chow. The goal was to determine the antiaging effect. The ...
5 CitationsSource
#1Eleonora Cremonini (UC Davis: University of California, Davis)H-Index: 12
#2Cesar G. Fraga (UBA: University of Buenos Aires)H-Index: 53
Last. Patricia I. Oteiza (UC Davis: University of California, Davis)H-Index: 47
view all 3 authors...
Abstract Emerging evidence supports a beneficial action of the flavan-3-ol (–)-epicatechin (EC) on insulin sensitivity and potential impact on the development/progression of type 2 diabetes (T2D). In humans, supplementation with EC-rich foods, extracts, and pure EC improves insulin sensitivity and glucose tolerance in normal weight, overweight, obese and T2D individuals. These effects of EC are also observed in rodent models of diet-induced obesity and T2D. The events involved in the development...
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