Pharmacological Tools to Modulate Autophagy in Neurodegenerative Diseases
Abstract
Considerable evidences suggest a link between autophagy dysfunction, protein aggregation, and neurodegenerative diseases. Given that autophagy is a conserved intracellular housekeeping process, modulation of autophagy flux in various model organisms have highlighted its importance for maintaining proteostasis. In postmitotic cells such as neurons, compromised autophagy is sufficient to cause accumulation of ubiquitinated aggregates, neuronal...
Paper Details
Title
Pharmacological Tools to Modulate Autophagy in Neurodegenerative Diseases
Published Date
Apr 1, 2020
Journal
Volume
432
Issue
8
Pages
2822 - 2842
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