Differential sensitivity of human islets from obese versus lean donors to chronic high glucose or palmitate

Background Due to the shortage of multi‐organ donors, human pancreatic islet transplantation has now been extended to islets originating from obese subjects. In this study, our aim is to compare the respective sensitivity of human islets from lean vs obese donors to chronic high glucose or high palmitate. Methods Human islets were isolated from pancreases harvested from brain‐dead multi‐organ donors. Islets were cultured during 72 hours in the...