Regulation of the cold-sensing TRPM8 channels by phosphoinositides and Gq-coupled receptors
Abstract
The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. This review discusses recent findings on the role of PI(4,5)P2 and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on...
Paper Details
Title
Regulation of the cold-sensing TRPM8 channels by phosphoinositides and Gq-coupled receptors
Published Date
Jan 1, 2020
Journal
Volume
14
Issue
1
Pages
79 - 86
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