Sirtuin-1 and Its Relevance in Vascular Calcification

Volume: 21, Issue: 5, Pages: 1593 - 1593
Published: Feb 26, 2020
Abstract
Vascular calcification (VC) is highly associated with cardiovascular disease and all-cause mortality in patients with chronic kidney disease. Dysregulation of endothelial cells and vascular smooth muscle cells (VSMCs) is related to VC. Sirtuin-1 (Sirt1) deacetylase encompasses a broad range of transcription factors that are linked to an extended lifespan. Sirt1 enhances endothelial NO synthase and upregulates FoxOs to activate its antioxidant...
Paper Details
Title
Sirtuin-1 and Its Relevance in Vascular Calcification
Published Date
Feb 26, 2020
Volume
21
Issue
5
Pages
1593 - 1593
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