α2A-Adrenoceptors Modulate Renal Sympathetic Neurotransmission and Protect against Hypertensive Kidney Disease

Significance Statement Increased sympathetic nerve activity plays an important role in hypertension and kidney disease. To investigate the role of α 2A-adrenergic receptors ( α 2A-adrenoceptors) in hypertension and hypertensive kidney disease, the authors induced angiotensin II (AngII)–dependent hypertension in wild-type and α 2A-adrenoceptor–knockout mice. Deletion of α 2A-adrenoceptors increased AngII-facilitated renal NE release and activated...