O-GlcNAcase contributes to cognitive function in Drosophila
Abstract
O-GlcNAcylation is an abundant post-translational modification in neurons. In mice, an increase in O-GlcNAcylation leads to defects in hippocampal synaptic plasticity and learning. O-GlcNAcylation is established by two opposing enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). To investigate the role of OGA in elementary learning, we generated catalytically inactive and precise knockout Oga alleles (OgaD133N and OgaKO, respectively) in...
Paper Details
Title
O-GlcNAcase contributes to cognitive function in Drosophila
Published Date
Jun 1, 2020
Volume
295
Issue
26
Pages
8636 - 8646
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