Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut
Abstract
Adult tissues and organs rely on resident stem cells to generate new cells that replenish damaged cells. To maintain homeostasis, stem cell activity needs to be tightly controlled throughout the adult life. Here, we show that the membrane-associated kinase Gilgamesh (Gish)/CK1γ maintains Drosophila adult midgut homeostasis by restricting JNK pathway activity and that Gish is essential for intestinal stem cell (ISC) maintenance under stress...
Paper Details
Title
Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut
Published Date
Feb 21, 2020
Journal
Volume
219
Issue
4
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