Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
Abstract
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important...
Paper Details
Title
Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
Published Date
Mar 1, 2020
Volume
106
Issue
3
Pages
389 - 404
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