Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

Published on Mar 5, 2020in American Journal of Human Genetics9.924
· DOI :10.1016/J.AJHG.2020.02.006
Chen Li1
Estimated H-index: 1
(University of Cambridge),
Svetlana Stoma1
Estimated H-index: 1
(University of Leicester)
+ 93 AuthorsAlexessander Couto Alves24
Estimated H-index: 24
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) 350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.
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