Telomere maintenance in interplay with DNA repair in pathogenesis and treatment of colorectal cancer
Abstract
Colorectal cancer (CRC) continues to be one of the leading malignancies and causes of tumour-related deaths worldwide. Both impaired DNA repair mechanisms and disrupted telomere length homeostasis represent key culprits in CRC initiation, progression and prognosis. Mechanistically, altered DNA repair results in the accumulation of mutations in the genome and, ultimately, in genomic instability. DNA repair also determines the response to...
Paper Details
Title
Telomere maintenance in interplay with DNA repair in pathogenesis and treatment of colorectal cancer
Published Date
Feb 21, 2020
Journal
Volume
35
Issue
3
Pages
261 - 271
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Notes
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