Laminin 521 enhances self-renewal via STAT3 activation and promotes tumor progression in colorectal cancer
Abstract
Remodeling of basement membrane proteins contributes to tumor progression towards the metastatic stage. One of these proteins, laminin 521 (LN521), sustains embryonic and induced pluripotent stem cell self-renewal, but its putative role in cancer is poorly described. In the present study we found that LN521 promotes colorectal cancer (CRC) cell self-renewal and invasion. siRNA-mediated knockdown of endogenously-produced laminin alpha 5, as well...
Paper Details
Title
Laminin 521 enhances self-renewal via STAT3 activation and promotes tumor progression in colorectal cancer
Published Date
Apr 1, 2020
Journal
Volume
476
Pages
161 - 169
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