Expeditious synthesis and kinetic study of biodegradable amide 2,2-( (3-(2-((carboxymethyl)amino)-2-oxoethyl)-3-hydroxypentanedioyl)bis(azanediyl) diacetic acid (COHBDA) under ultrasound irradiation

The amide bond formation has vital importance in chemical synthesis and industry. Amidation reaction with atom economic efficiency is the greatest demanding due to the use of hazardous coupling agent and intolerable waste by product in the reaction. Hence looks forward to its development in a more sustainable approach. In answer to this intense demand, we here in reveal an economically simple and environmentally friendly expeditious one-pot...