Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study
Abstract
Background and aimsApolipoprotein A-I (apoA-I) infusions represent a potential novel therapeutic approach for the prevention of coronary artery disease (CAD). Although circulating apoA-I concentrations inversely associate with risk of CAD, the evidence base of this representing a causal relationship is lacking. The aim was to assess the causal role of apoA-I using human genetics.MethodsWe identified a variant (rs12225230) in APOA1 locus that...
Paper Details
Title
Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study
Published Date
Apr 1, 2020
Journal
Volume
299
Pages
56 - 63
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