Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling.
Abstract
Formylpeptide receptors (FPRs) as G protein-coupled receptors (GPCRs) can recognize formylpeptides derived from pathogens or host cells to function in host defense and cell clearance. In addition, FPRs, especially FPR2, can also recognize other ligands with a large chemical diversity generated at different stages of inflammation to either promote or resolve inflammation in order to maintain a balanced inflammatory response. The mechanism...
Paper Details
Title
Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling.
Published Date
Feb 14, 2020
Journal
Volume
11
Issue
1
Pages
885 - 885
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