MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3
Abstract
Central precocious puberty (CPP) refers to a human syndrome of early puberty initiation with characteristic increase in hypothalamic production and release of gonadotropin-releasing hormone (GnRH). Previously, loss-of-function mutations in human MKRN3, encoding a putative E3 ubiquitin ligase, were found to contribute to about 30% of cases of familial CPP. MKRN3 was thereby suggested to serve as a 'brake' of mammalian puberty onset, but the...
Paper Details
Title
MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3
Published Date
Feb 14, 2020
Journal
Volume
7
Issue
3
Pages
671 - 685
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