Rationale for the advancement of PI3K pathway inhibitors for personalized chordoma therapy
Abstract
Chordomas are rare and serious tumors with few effective treatments outside of aggressive surgery and radiation. Targeted therapies may present a more effective option for a subset of patients with lesions possessing certain genetic biomarkers. A small molecule inhibitor library was tested in patient-derived UM-Chor1 cells to identify targeted therapies with potential efficacy. Targeted exome sequencing of UM-Chor1 and UM-Chor2 cells was...
Paper Details
Title
Rationale for the advancement of PI3K pathway inhibitors for personalized chordoma therapy
Published Date
Feb 17, 2020
Journal
Volume
147
Issue
1
Pages
25 - 35
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