HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation
Abstract
•HILPDA is a lipid-induced, physiological inhibitor of ATGL-mediated lipolysis•HILPDA-deficient macrophages show enhanced breakdown of triglycerides through ATGL•Reduced lipid storage in macrophages does not affect adipose tissue inflammation Obesity leads to a state of chronic, low-grade inflammation that features the accumulation of lipid-laden macrophages in adipose tissue. Here, we determined the role of macrophage lipid-droplet accumulation...
Paper Details
Title
HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation
Published Date
Feb 1, 2020
Journal
Volume
30
Issue
6
Pages
1811 - 1822.e6
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