The Acid Sphingomyelinase/ Ceramide System as Target for Ischemic Stroke Therapies

Published: Nov 29, 2019
Abstract
In this review, we summarize implications of the acid sphingomyelinase/ ceramide system in ischemic stroke. Acid sphingomyelinase catalyzes the formation of the bioactive sphingolipid ceramide which coalesces into membrane platforms and has a pivotal role in inflammation, cell signaling and death. Cerebral ischemia increases acid sphingomyelinase activity and elevates brain ceramide levels, which has been associated with the exacerbation of...
Paper Details
Title
The Acid Sphingomyelinase/ Ceramide System as Target for Ischemic Stroke Therapies
Published Date
Nov 29, 2019
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