Loss of smooth muscle α-actin effects on mechanosensing and cell–matrix adhesions
Abstract
Mutations in ACTA2, encoding smooth muscle α-actin, are a frequent cause of heritable thoracic aortic aneurysm and dissections. These mutations are associated with impaired vascular smooth muscle cell function, which leads to decreased ability of the cell to sense matrix-mediated mechanical stimuli. This study investigates how loss of smooth muscle α-actin affects cytoskeletal tension development and cell adhesion using smooth muscle cells...
Paper Details
Title
Loss of smooth muscle α-actin effects on mechanosensing and cell–matrix adhesions
Published Date
Feb 1, 2020
Volume
245
Issue
4
Pages
374 - 384
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