Dexmedetomidine Exerted Anti-arrhythmic Effects in Rat With Ischemic Cardiomyopathy via Upregulation of Connexin 43 and Reduction of Fibrosis and Inflammation

Background---Persistent myocardial ischemia occurred in post-myocardial infarction could lead to fatal ventricular arrhythmias like ventricular tachycardia and fibrillation and also has high rate of mortality. Dexmedetomidine (Dex), a highly selective α2-agonist, applied for daily anesthetic practice prevalently, was associated with a decrease in postoperative mortality and decreased incidence of postoperative complications and delirium in...