Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins
Abstract
The NAD-dependent deacetylase Sirtuin-2 (SIRT2) functions in diverse cellular processes including the cell cycle, metabolism, and has important roles in tumorigenesis and bacterial infection. SIRT2 predominantly resides in the cytoplasm but can also function in the nucleus. Consequently, SIRT2 localisation and its interacting partners may greatly impact its function and need to be defined more clearly. In this study we used mass spectrometry to...
Paper Details
Title
Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins
Published Date
Feb 10, 2020
Journal
Volume
10
Issue
1
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