Clonal hematopoiesis in cancer

•The clinical implications of clonal hematopoiesis in the cancer setting are reviewed.•The biologic interplay between clonal hematopoiesis and development of solid and blood-related tumors is discussed.•Strategies for managing clonal hematopoiesis with risk-directed approaches are explored. Clonal hematopoiesis is a common premalignant condition defined by the abnormal expansion of clonally derived hematopoietic stem cells carrying somatic...