Cancer as a disease of old age: changing mutational and microenvironmental landscapes
Abstract
Why do we get cancer mostly when we are old? According to current paradigms, the answer is simple: mutations accumulate in our tissues throughout life, and some of these mutations contribute to cancers. Although mutations are necessary for cancer development, a number of studies shed light on roles for ageing and exposure-dependent changes in tissue landscapes that determine the impact of oncogenic mutations on cellular fitness, placing...
Paper Details
Title
Cancer as a disease of old age: changing mutational and microenvironmental landscapes
Published Date
Feb 11, 2020
Journal
Volume
122
Issue
7
Pages
943 - 952
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