Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression
Abstract
Lipid droplets (LDs) store lipids for energy and are central to cellular lipid homeostasis. The mechanisms coordinating lipid storage in LDs with cellular metabolism are unclear but relevant to obesity-related diseases. Here we utilized genome-wide screening to identify genes that modulate lipid storage in macrophages, a cell type involved in metabolic diseases. Among ∼550 identified screen hits is MLX, a basic helix-loop-helix leucine-zipper...
Paper Details
Title
Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression
Published Date
Mar 1, 2020
Journal
Volume
77
Issue
6
Pages
1251 - 1264.e9
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