Estimating Urine Albumin-to-Creatinine Ratio from Protein-to-Creatinine Ratio: Development of Equations using Same-Day Measurements

Significance Statement The urine albumin-to-creatinine ratio (ACR) is the preferred metric for quantifying albuminuria, and it also has been incorporated into equations to predict risk of kidney failure. However, often only the protein-to-creatinine ratio (PCR) is available. Previous studies have described the association between ACR and PCR, although none have provided a method to estimate ACR from PCR that accounts for the nonlinear...