Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
Abstract
The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures that represent mutation types that co-occur in the same tumours. However, it remains unclear how mutation processes change during cancer evolution due to the lack of reliable methods to reconstruct evolutionary trajectories of mutational signature activity. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole...
Paper Details
Title
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
Published Date
Feb 5, 2020
Journal
Volume
11
Issue
1
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