Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors
Abstract
Background Gastrointestinal stromal tumor (GIST) initiation and evolution is commonly framed by KIT/PDGFRA oncogenic activation, and in later stages by the polyclonal expansion of resistant subpopulations harboring KIT secondary mutations after the onset of imatinib resistance. Thus, circulating tumor (ct)DNA determination is expected to be an informative non-invasive dynamic biomarker in GIST patients. Methods We performed amplicon-based...
Paper Details
Title
Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors
Published Date
Feb 5, 2020
Journal
Volume
20
Issue
1
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