Original paper
Poly‐aneuploid cancer cells promote evolvability, generating lethal cancer
Abstract
Cancer cells utilize the forces of natural selection to evolve evolvability allowing a constant supply of heritable variation that permits a cancer species to evolutionary track changing hazards and opportunities. Over time, the dynamic tumor ecosystem is exposed to extreme, catastrophic changes in the conditions of the tumor—natural (e.g., loss of blood supply) or imposed (therapeutic). While the nature of these catastrophes may be varied or...
Paper Details
Title
Poly‐aneuploid cancer cells promote evolvability, generating lethal cancer
Published Date
Feb 22, 2020
Journal
Volume
13
Issue
7
Pages
1626 - 1634
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Notes
History