Multiple Input Sensing and Signal Integration Using a Split Cas12a System
Abstract
The ability to integrate biological signals and execute a functional response when appropriate is critical for sophisticated cell engineering using synthetic biology. Although the CRISPR-Cas system has been harnessed for synthetic manipulation of the genome, it has not been fully utilized for complex environmental signal sensing, integration, and actuation. Here, we develop a split dCas12a platform and show that it allows for the construction of...
Paper Details
Title
Multiple Input Sensing and Signal Integration Using a Split Cas12a System
Published Date
Apr 1, 2020
Journal
Volume
78
Issue
1
Pages
184 - 191.e3
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