Baseline sputum eosinophil + neutrophil subgroups’ clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort

Cellular analysis of induced sputum allows noninvasive assessment of airway inflammation in comprehensively phenotyped subjects with different levels of asthma severity. Sputum analysis in a subset of subjects in the cross-sectional Severe Asthma Research Program (SARP)1 + 2 revealed combined higher eosinophil and neutrophil percentages associated with more severe asthma phenotypes including lower lung function and greater health care...