Brain structure and symptom dimensions in borderline personality disorder

Background. Borderline personality disorder (BPD) presents with symptoms across different domains, whose neurobiology is poorly understood. Methods. We applied voxel-based morphometry on high-resolution magnetic resonance imaging scans of 19 female BPD patients and 50 matched female controls. Results. Group comparison showed bilateral orbitofrontal gray matter loss in patients, but no significant changes in the hippocampus. Voxel-wise...