Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss
Abstract
von Hippel-Lindau (VHL) is a critical tumor suppressor in clear cell renal cell carcinomas (ccRCCs). It is important to identify additional therapeutic targets in ccRCC downstream of VHL loss besides hypoxia-inducible factor 2α (HIF2α). By performing a genome-wide screen, we identified Scm-like with four malignant brain tumor domains 1 (SFMBT1) as a candidate pVHL target. SFMBT1 was considered to be a transcriptional repressor but its role in...
Paper Details
Title
Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss
Published Date
Mar 1, 2020
Journal
Volume
77
Issue
6
Pages
1294 - 1306.e5
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