3D Superresolution Studies of the Effect of SERINC5 on Env Glycoprotein Distribution on HIV-1 Particles

HIV-1 envelope glycoprotein (Env) initiates viral fusion to target cells following the sequential interactions with CD4 and coreceptors. It has been shown that, following HIV-1 maturation, Env is unevenly distributed on the virus surface and suggested that such Env clustering facilitates viral fusion by increasing the local density of these proteins, which may act cooperatively to form a fusion pore. Here we performed super-resolution imaging of...