Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease
Abstract
Inheritance of apolipoprotein E4 (APOE4) is a major risk factor for development of Alzheimer's disease (AD). This lipoprotein, in contrast to apoE2, has arginine residues at positions 112 and 158 in place of cysteines in the latter isoform. In apoE3, the Cys at residue 158 is replaced by an arginine residue. This differential amino acid composition of the three genotypes of APOE have profound influence on the structure, binding properties, and...
Paper Details
Title
Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease
Published Date
May 1, 2020
Journal
Volume
138
Pages
104795 - 104795
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