Oral manifestations and clinical progression of a rare double-hit B-cell lymphoma: a case report and review of the literature

Double-hit (DH) lymphoma is a rare subtype of B-cell lymphoma characterized by the chromosomal rearrangement of c-Myc and Bcl-2, and/or Bcl-6. c-Myc is an oncogene that keeps cells proliferative. Bcl-2 and Bcl-6 grant cells antiapoptotic features. The concurrent expression of these genes and their synergistic effect make DH lymphoma refractory to traditional chemotherapy, with an extremely poor prognosis. Here, we present a case of DH lymphoma...