Effect of the patatin‐like phospholipase domain containing 3 gene (PNPLA3) I148M polymorphism on the risk and severity of nonalcoholic fatty liver disease and metabolic syndromes: A meta‐analysis of paediatric and adolescent individuals

Summary Background The effect of the patatin‐like phospholipase domain containing 3 gene ( PNPLA3 ) I148M polymorphism on the risk and severity of paediatric and adolescent nonalcoholic fatty liver disease (NAFLD) remains inconclusive. Objectives We aimed to estimate the effect of this polymorphism not only on early‐onset NAFLD risk and severity but also on metabolic syndromes susceptibility. Methods A systematic literature search was performed...