Trained Immunity: Linking Obesity and Cardiovascular Disease across the Life-Course?

Obesity, a chronic inflammatory disorder, is the most prevalent modifiable risk factor for cardiovascular disease throughout the life-course; long-term outcomes following lifestyle interventions have generally been disappointing. Inhibition of inflammation has been shown to decrease cardiovascular risk in patients with a residual inflammatory risk. Recent studies have demonstrated that the innate immune system can adopt a long-term memory...