Differential interactions of the β‐lactam cloxacillin with human renal organic anion transporters (OATs)

The β‐lactam penicillin antibiotic cloxacillin (CLX) presents wide inter‐individual pharmacokinetics variability. To better understand its molecular basis, the precise identification of the detoxifying actors involved in CLX disposition and elimination would be useful, notably with respect to renal secretion known to play a notable role in CLX elimination. The present study was consequently designed to analyze the interactions of CLX with the...