Towards improved hepatocyte cultures: Progress and limitations
Abstract
Hepatotoxicity is among the most frequent reasons for drug withdrawal from the market. Therefore, there is an urgent need for reliable predictive in vitro tests, which unfailingly identify hepatotoxic drug candidates, reduce drug development time, expenses and the number of test animals. Currently, human hepatocytes represent the gold standard. However, the use of hepatocytes is challenging since the cells are not constantly available and lose...
Paper Details
Title
Towards improved hepatocyte cultures: Progress and limitations
Published Date
Apr 1, 2020
Journal
Volume
138
Pages
111188 - 111188
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