Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons
Abstract
Imprinted genes with parental-biased allelic expression are frequently co-regulated and enriched in common biological pathways. Here, we functionally characterize a large cluster of microRNAs (miRNAs) expressed from the maternally inherited allele ("maternally expressed") to explore the molecular and cellular consequences of imprinted miRNA activity. Using an induced neuron (iN) culture system, we show that maternally expressed miRNAs from the...
Paper Details
Title
Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons
Published Date
Apr 1, 2020
Journal
Volume
78
Issue
1
Pages
85 - 95.e8
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