Characterization of three‐dimensional rat central nervous system culture maturation, with applications to monitor cholinergic integrity
Abstract
Studying age‐related neuropathologies in vitro requires a three‐dimensional (3D) culture system presenting mature phenotypes. In this study, we aimed to determine whether aged reaggregate cultures physiologically represent mature brain tissue. Results support that embryo‐derived rat central nervous system (CNS) reaggregate cultures develop into mature‐like tissues, comparable to in vivo maturation, including the following characteristics: (a)...
Paper Details
Title
Characterization of three‐dimensional rat central nervous system culture maturation, with applications to monitor cholinergic integrity
Published Date
Feb 13, 2020
Journal
Volume
36
Issue
4
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